Methods We studied 76 patients with stage I CKD (group I: 22 non-diabetic, 14 male, 8 female; mean age 12.8±0.6 years; group II: 19 type I diabetic, 13 male, 6 female; mean age 14.2±0.7 years; group III (controls): 25 healthy children, 14 male, 11 female; mean age 13.1±0.7 years) by M-mode and pulsed Doppler echocardiography.
Results Comparison of CKD patients and controls showed increased LV mass index in groups I and II (86.91±15.76 g/m2, p<0.05; 82.8±15.76 g/m2, p<0.05, respectively). The LV diastolic function (LVDF) was decreased. A velocity integral (A-VTI) (group I: 0.033±0.000037 m2, p<0.05; group II: 0.025±0.000055 m2, p<0.01), E deceleration time (DT) (group I: 0.118±0.0031 s, p<0.01; group II: 0.113±0.000171 s, p<0.05), E acceleration time (AT) (group II: 0.126±0.0018 s, p<0.05) were higher and ratio of E velocity integral to A-VTI (group I: 3.014±0.038, p<0.05), ADT (group II: 0.043±0.000046 s, p<0.05) were lower compared to controls. Increased myocardial stiffness was discovered by assessment of EAT to 1/2 of EDT ratio (group I: 1.7±0.01, p<0.05; group II: 3.11±0.073, p<0.001).
Conclusions The LVDF is already present in stage I CKD patients. non-diabetic and diabetic CKD patients have similar changes in myocardial function, which are more pronounced in diabetes due to serious metabolic disorders.
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