Article Text

  1. G Cavallaro1,
  2. E Agazzani1,
  3. L Andaloro1,
  4. S Boccacci1,
  5. C Bottura1,
  6. E Cerini1,
  7. G Cristofori1,
  8. P Mussini1,
  9. F Sacco1,
  10. A Plantulli1
  1. 1Neonatal Intensive Care Unit, Carlo Poma Hospital, Mantova, Italy


Objective Mild hypothermia (MH) (rectal temperature 33–34 C) appears neuroprotective. Deep hypothermia (DH) (rectal temperature 30–33 C) could be a new therapeutic strategy for treating severe hypoxic-ischemic term infants. The aim of this study was to describe ventilator changes during DH and MH.

Methods 28 term asphyxiated newborns were enrolled: 20 DH and 8 MH. Mechanical ventilation was set to maintain an arterial oxygen saturation of 92–95% with PaO2 between 50 and 60 mmHg and PaCO2 between 40 and 45 mmHg.

Results 14 DH (70%) and 4 MH patients (50%) were treated with SIMV. In the DH group, 7 patients (35%) were maintained in room air and 13 (65%) required oxygen (FiO2 0.27–1.0). In MH group, 4 cases (50%) required oxygen (FiO2 0.22–1.0) and 4 (50%) room air. Mean of hours of ventilation were 48.11 (44.11) hrs in DH and 105.5 (69.69) hrs in MH; there was no statistically significant difference between the two groups (p = 0.095). Mean of hours of oxygen required were 88.5 (91.95) hrs in DH and 231 (58.298) hrs in MH (p = 0.010). There was no statistical difference in the highest quantity of FiO2 between the DH and MH (P = 0.747).

Conclusions Mild and deep hypothermia did not produce any change in mean of hours of ventilation. However there is a statistically significant difference in hours of oxygen support. This discrepancy is probably correlated to a reduction in oxygen consumption, for a decrease in metabolic state in DH group compared with MH group.

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