Introduction Chronic granulomatous disease (CGD) is characterized by the ability of neutrophils and monocytes to ingest but their inability to kill catalase-positive microorganisms because of a defect in the generation of microbial oxygen metabolites. CGD is a rare disease with an incidence of four to five per million individuals, caused by genes affecting one x-linked and three autosomal recessive chromosomes.
Case report We report a 2/5-year-old girl with multiple liver abscess and final diagnosis of chronic granulomatous disease (NBT activity 0% and DHR test was positive)
Conclusion Any patient with recurrent or unusual pneumonia, lymphadenitis, hepatic abscesses, osteomyelitis at multiple sites, a family history of recurrent infections, or unusual infections with catalase- positive organisms (e.g. S. aureus) requires evaluation for this disorder.
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