Article Text

  1. K Mahlouji1,
  2. M Mehrazma1,
  3. R Taghipour1,
  4. K Salarian1
  1. 1Ali-Asghar Hospital, Medical Science University of Iran, Tehran, Iran


Introduction Chronic granulomatous disease (CGD) is characterized by the ability of neutrophils and monocytes to ingest but their inability to kill catalase-positive microorganisms because of a defect in the generation of microbial oxygen metabolites. CGD is a rare disease with an incidence of four to five per million individuals, caused by genes affecting one x-linked and three autosomal recessive chromosomes.

Case report We report a 2/5-year-old girl with multiple liver abscess and final diagnosis of chronic granulomatous disease (NBT activity 0% and DHR test was positive)

Conclusion Any patient with recurrent or unusual pneumonia, lymphadenitis, hepatic abscesses, osteomyelitis at multiple sites, a family history of recurrent infections, or unusual infections with catalase- positive organisms (e.g. S. aureus) requires evaluation for this disorder.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.