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Human immunodeficiency virus (HIV)-infected children are more likely to develop severe varicella and to die when infected than otherwise healthy children.1 2 In the absence of universal immunisation varicella remains prevalent.3 Secondary prophylaxis in exposed high-risk patients is expensive, invasive, carries the risk of side-effects and may not be implemented reliably. Primary prophylaxis with live-attenuated varicella vaccine has been shown to be safe and immunogenic and effective against both primary varicella and zoster recurrences in HIV-infected children …
Competing interests: AF undertakes clinical research and has spoken at meetings sponsored by vaccine manufacturers who make varicella vaccines and has also done advisory work for them. He has not received any personal payments for this work.
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