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Developing and introducing evidence based clinical practice guidelines for serious illness in Kenya
  1. Grace Irimu1,2,
  2. Annah Wamae3,
  3. Aggrey Wasunna1,
  4. Fred Were1,
  5. Stephen Ntoburi2,
  6. Newton Opiyo2,
  7. Philip Ayieko2,
  8. Norbert Peshu2,
  9. Mike English1,2,4
  1. 1
    Department of Paediatrics and Child Health, College of Health Sciences, University of Nairobi, Republic of Kenya
  2. 2
    Centre for Geographic Medicine Research – Coast, KEMRI/Wellcome Trust Research Programme, PO Box 230, Kilifi and PO Box 43640, Nairobi, Republic of Kenya
  3. 3
    Division of Child Health, Ministry of Health, Republic of Kenya
  4. 4
    Department of Paediatrics, University of Oxford, Oxford, UK
  1. Dr Grace Irimu, Centre for Geographic Medicine Research – Coast, KEMRI/Wellcome Trust Research Programme, PO Box 230, Kilifi and PO Box 43640, Nairobi, Republic of Kenya; girimu{at}

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Kenya, in common with many developing countries, has committed itself to Millennium Development Goal (MDG)-4, which calls for a two-third reduction in 1990 mortality levels in under 5-year-old children by 2015.1 Improving the management of common severe childhood illnesses is one of many strategies likely to be needed to achieve this goal since hospital mortality rates as high as 15% are reported.2 3 Two further points also suggest the potential value of improved basic care to improve outcomes. First, the majority of deaths are attributable to a handful of illnesses and second, assessments demonstrate that the quality of care provided to children in low-income countries is often poor and has considerable scope for improvement.3 4

Clinical practice guidelines (CPGs) are intended to assist the health provider in evidence-based decision making and promote the provision of optimal care. Previous studies have shown that adherence to such evidence-based guidelines is associated with improved health outcomes.57 For some conditions such as pneumonia8 and diarrhoea,9 10 the World Health Organization has made CPGs available for many years. In 2000 evidence and expert opinion were used to provide comprehensive advice on the care of sick children in hospital with common conditions.11 However, few hospitals or health workers in Kenya have access to either the WHO recommendations or modern local practice guidelines3 and it is known that a wide range of factors affect the actual ability to improve care and outcomes.1215

We therefore aimed to develop simple CPGs for conditions commonly associated with mortality in Kenyan hospitals and an in-service training package to facilitate their implementation. The effect on quality of hospital care of a multifaceted intervention project (including these CPGs and training) is the subject of ongoing research. Here we report the …

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