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Balfour-Lynn’s review1 underlines the benefits of neonatal screening programmes for cystic fibrosis (CFNSP). However, long-term clinical outcomes still need to be clarified. In particular, only a few published studies have compared the clinical outcomes at age 15 years of screened and non-screened cystic fibrosis (CF) patients.2–4 In Tuscany, Italy (3.5 million inhabitants, CF incidence 1 in 4144)5 a CFNSP has been carried out since 1984 together with a centralised follow-up programme. We wanted to evaluate the clinical benefits of CFNSP in an entire population of CF patients 15 years after diagnosis. To this purpose, we compared the clinical conditions of CF patients born in Tuscany since the introduction of the CFNSP and diagnosed by screening with those of patients followed since diagnosis by our centre and born in the same period but diagnosed …
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