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We welcome the recommendation to discontinue routine antibiotic prophylaxis in paediatric urinary tract infection, as mentioned in a review of the National Institute of Health and Clinical Excellence (NICE) guidance on this subject.1 In one of our East London paediatric accident and emergency departments, the incidence of trimethoprim resistance in urinary infections increased from 30% in 1999/2000 to over 40% in 2006/7. This is in line with an increase from 24% in 1996 to 31.6% in 2000 from another London hospital.2 As for adults, it can be queried whether …
Competing interests: None.