Article Text

PDF

Effectiveness and cost-effectiveness of height-screening programmes during the primary school years: a systematic review
  1. D Fayter1,
  2. J Nixon1,
  3. S Hartley2,
  4. A Rithalia1,
  5. G Butler3,
  6. M Rudolf4,
  7. P Glasziou5,
  8. M Bland6,
  9. L Stirk1,
  10. M Westwood1
  1. 1
    Centre for Reviews and Dissemination, University of York, York, UK
  2. 2
    Clinical Trials Research Unit, University of Leeds, 17 Springfield Mount, Leeds, UK
  3. 3
    Institute of Health Sciences, University of Reading, London Road, Reading, UK
  4. 4
    Department of Community Paediatrics, University of Leeds, Belmont House, 3–5 Belmont Grove, Leeds, UK
  5. 5
    Department for Primary Health Care, University of Oxford, Old Road, Headington, Oxford, UK
  6. 6
    Department of Health Sciences, University of York, Heslington, York, UK
  1. Dr Marie Westwood, Senior Research Fellow, Centre for Reviews and Dissemination, University of York, York, YO10 5DD; mew3{at}york.ac.uk

Abstract

Objective: To determine the effectiveness and cost-effectiveness of height screening (of children aged 4 to 11) to identify height-related conditions.

Design: Systematic review and economic modelling.

Setting and intervention: We included published and unpublished screening studies of any design, except case reports, conducted in any setting that measured children’s height as part of a population-level assessment. Studies were identified by electronic database searches, contact with experts and from bibliographies of retrieved studies.

Participants: Children aged between 4 and 11 years.

Outcome measures: Diagnostic yield of height-related conditions and change in quality of life, as measured by quality-adjusted life years (QALYs), for early versus late treatment of underlying conditions.

Results: Twelve studies described a height-screening programme and provided data on the diagnostic yield of newly diagnosed height-related conditions. Where reported, yield for growth-hormone deficiency (per 1000 children screened) ranged from 0.05 (1 in 20 000) to 0.62 (approximately 1 in 1500) and for Turner syndrome (per 1000 children screened) was between 0.02 (1 in 50 000) and 0.07 (approximately 1 in 14 000). As a secondary gain, children with other potentially treatable conditions were identified; diagnostic yields ranged from 0.22 to 1.84 per 1000 children screened. Three studies did not detect any new cases, but all of these studies had methodological limitations. Economic modelling suggested that height screening is associated with health improvements and is cost effective for a willingness to pay threshold of £30 000 per QALY.

Conclusions: This review indicates the utility and acceptable cost-effectiveness of height screening arising from increased detection of height-related disorders and secondary pick-up of other undiagnosed conditions. Further research is needed to obtain more reliable data on quality of life gains and costs associated with early interventions for height-related conditions. The exact role of height-screening programmes in improving child health remains to be determined.

View Full Text

Statistics from Altmetric.com

Supplementary materials

  • web only table 93/4/278

    Files in this Data Supplement:

Footnotes

  • Additional tables are published online only athttp://adc.bmj.com/content/vol93/issue4

  • Funding: The study was funded by the NHS R & D under its HTA programme but the authors’ work was conducted independently of the funders.

  • Competing interests: GB has previously received educational and research funding from all the major manufacturers of growth hormone. All other authors have nothing to declare.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Atoms
    Howard Bauchner