Article Text

Download PDFPDF
Pallidal stimulation for pantothenate kinase-associated neurodegeneration dystonia
  1. C Isaac1,2,
  2. I Wright2,3,
  3. D Bhattacharyya4,
  4. P Baxter3,
  5. J Rowe4
  1. 1
    Clinical Neuropsychology Services, Royal Hallamshire Hospital, Sheffield, UK
  2. 2
    Clinical Psychology Unit, Department of Psychology, University of Sheffield, Sheffield, UK
  3. 3
    Ryegate Children’s Centre, Sheffield Children’s NHS Trust, Sheffield, UK
  4. 4
    Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK
  1. Jeremy Rowe, Department of Neurosurgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; Jeremy.Rowe{at}


Pantothenate kinase-associated neurodegeneration is associated with generalised dystonia and cognitive deterioration. Limited evidence suggests that pallidal deep brain stimulation improves physical functioning. This is a report of the assessment and treatment of a severely affected patient in whom pallidal deep brain stimulation improved both physical and psychosocial functioning. Implications for treatment are briefly discussed.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: None.

  • Patient consent: Consent has been obtained for publication of fig 1.