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Ceftriaxone drug alert: no longer for first line use in meningococcal sepsis
  1. S N Faust1,
  2. A J Pollard2,
  3. S Nadel3,
  4. N Ninis3,
  5. M Levin3
  1. 1
    Welcome Trust Clinical Research Faculty, University of Southampton, Southampton, UK
  2. 2
    Department of Paediatrics, University of Oxford, Oxford, UK
  3. 3
    Department of Paediatrics, Imperial College School of Medicine, St Mary’s Hospital, London, UK
  1. Saul N Faust, Wellcome Trust Clinical Research Facility, Mailpoint 218, Level C, West Wing, Southampton University Hospital, Tremona Road, Southampton SO16 6YD, UK; s.faust{at}

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Although UK and international high income country practice has been to recommend ceftriaxone or cefotaxime as first line therapy for the initial treatment of paediatric sepsis, the US FDA has issued an alert1 that has led to changes in the US label for ceftriaxone.2 Due to concerns regarding the potential for calcium chelation …

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  • Competing interests: None declared.

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