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Safety of anti-infective agents for skin preparation in premature infants
  1. S Upadhyayula1,
  2. M Kambalapalli2,
  3. C J Harrison2
  1. Rotherham General Hospital, Rotherham, UK;
  2. Rotherham General Hospital, Rotherham, UK

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A baby sustained extensive skin burns after the use of a skin preparation (alcoholic chlorhexidine). Following this event the hospital started using an aqueous preparation of chlorhexidine 0.05%. Was this the right choice and what is the evidence for the use of this or any other skin preparation in preterm infants?

Structured clinical question

In preterm infants of <28 weeks’ gestation [patient] what is the choice of skin preparation prior to invasive procedures on the unit [intervention] in terms of safety or least complications and prevention of infection [outcome]?

Search strategy and outcome

Primary source: Medline (1956–2005), MeSH terms were used. An advance search was carried out and close matches from mapping were chosen and another search was carried out using explode and major subheadings. Secondary sources: Cochrane and EMBASE.

Search terms: Premature and anti-infective agents and invasive procedures and safety and complications.

Search outcome: Only four hits matched all our search criteria. We further searched for trials that looked at the safety and efficacy of different antimicrobials …

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  • Bob Phillips