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Does a teething child need serious illness excluding?
  1. M Tighe1,
  2. M F E Roe2
  1. 1St Mary’s Hospital, Portsmouth, UK; mpt195{at}
  2. 2Southampton General Hospital, Portsmouth, UK

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An 8-month-old girl has been referred to the emergency department by her general practitioner with a 24-h history of drooling, intermittent screaming and low-grade fever (maximum 38.2°C). She is refusing solids and her fluid intake has decreased. Her parents report that her nappies are drier than normal but her stools are looser. She has had some relief from oral paracetamol syrup. Her parents suspect teething.

On examination she is found to be miserable. She is not clinically dehydrated and has a diffusely hyperaemic right cheek. On examination of her mouth you notice a raw area on her upper gums where two teeth are erupting. No other abnormal clinical signs are noted.

You agree that the infant may be teething, but wonder if there are any symptoms that would distinguish between teething and an alternative diagnosis.

In an infant with suspected teething (patient), are there any symptoms or signs pathognomonic of teething (assessment) that would allow for the reassurance of parents without further management (outcome)?

Secondary sources: none.

Medline (1966–September 2006) using the Ovid interface was analysed for articles containing the keywords “(teething or tooth) and symptom$ and (infant or baby)”. Limits included human and English language only.

In total, 78 articles were identified, of which teething was the main focus in 21 articles. There were three prospective studies1–3 and two retrospective studies45 examining the link between teething and systemic symptoms in the community (table 1). These form the basis of our evidence-based review. Another retrospective review presented the diagnoses of 50 children admitted to hospital with a presenting complaint of teething.6 This is discussed separately.

Table 1

 Studies examining the link between teething and systemic symptoms

One previous letter commented on the three prospective trials.7 Nine articles found were questionnaire studies on beliefs of local populations (both health professional and parental) regarding teething. Studies not discussed here include cytokine levels in the gingival area (n = 1), effects of mercury exposure on teething (n = 1), misuse of teething gel (n = 1), herpes stomatitis mimicking teething (n = 1), and a nursing article on teething that was purely descriptive. One article summarised the study by Wake et al8 and is also not discussed.


From this review, it is apparent that a number of children develop symptoms that their parents/carers attribute to teething. However, although our analysis shows that a variety of symptoms may occur contemporaneously with teething, there is no pattern of symptoms manifesting in all the studies that can reliably distinguish teething from any other potential cause of the symptoms. The most robust study by Wake et al1 did not confirm any notable association between teething and systemic symptoms. However, the mean age of the children enrolled was 14.4 months, which is older than that in other studies. The mean age of eruption of the first tooth, usually a lower incisor, is around 8 months and so this study may have missed the majority of first-tooth episodes. Peretz et al4 did analyse symptoms with respect to age, and although the data are retrospective their results suggest that teething symptoms peak around 12–15 months.

The largest study by Macknin et al2 showed significant (p<0.01) associations with biting, drooling, gum rubbing, irritability, sucking and temperature >37.5°C. However, attributing these symptoms to teething was not possible as no symptom occurred in >35% of infants during each teething period, and no symptom occurred >20% more often in the teething period than in the non-teething period.

The results presented by Jaber et al3 considered only temperature and only included children before the emergence of their first tooth. This was despite a daily record kept by the parents of a number of other symptoms, including diarrhoea. The data presented in graph form suggest that there is an increase in temperature at the time of the first tooth eruption, and the 95% confidence intervals (37.33°C to 37.86°C) exceeded the mean temperatures on days before the tooth eruption (⩽37.1°C). However, there are no confidence intervals for the mean temperatures before the eruption, and it is not possible to determine the relevance of these data.

The conclusions of all the prospective studies are that no specific symptoms or clusters of symptoms can reliably predict the emergence of a tooth. Furthermore, symptoms that might be attributed to teething are not serious, and the presence of fever (>38.5°C) or other clinically important symptoms are very unlikely to be caused by teething. This is borne out by Swann,6 who reviewed 50 children admitted to hospital with a presenting complaint of teething. In 48 children, a medical condition was diagnosed, including one case of bacterial meningitis.

Nine studies assessed perceptions in certain populations from countries including Nigeria,9–11 Australia,1213 Turkey,14 the USA,15 Israel16 and Guinea-Bissau.17 These studies are subjective and open to recall bias and hence are not included in the evidence base of this report. However, they do demonstrate the widely held secular view that teething can cause many clinical symptoms—for example, in the Guinea-Bissau population, only 33% of parents with “severely dehydrated” children would seek medical help if they thought that the dehydration was secondary to teething. On the other hand, teething may be a label for minor ailments and provide a rationale that parents can accept. This label may also provide confidence to the carers of children that the child can be managed without resorting to formal healthcare.1

Our critical appraisal found two large well-designed studies that show that teething is unlikely to be associated with relevant clinical symptoms and signs, and one smaller study which showed a possible association between temperature and the eruption of the first tooth. The two large retrospective studies were not sufficiently robust to provide further information. We also identified one paper highlighting the risks of attributing relevant medical symptoms to teething.

This review suggests that there is no evidence that teething can be “identified” as the source of symptoms in a child. We agree with previous authors and recommend that this is a diagnosis of exclusion, to be made with caution. We acknowledge that this message may conflict with many firmly held beliefs of our patients’ parents and of other colleagues, but this review has shown that if a child is ill enough to be admitted to hospital, other organic causes need to be excluded, so that the child is managed appropriately. We also suggest that visualisation of the gums should be part of the clinical examination of the mouth and pharynx in young children to deal with the possible parental concerns, as teething has often been diagnosed on the basis of symptoms alone.


No evidence is available to suggest that there are any symptoms or signs specific to teething that allow a diagnosis to be made confidently in a child without excluding other organic pathology (grade B).


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  • Bob Phillips

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