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Neurological disorders presenting mainly in adolescence


The aim of this review is to discuss some of the neurological diseases that present mainly in the adolescent period. The article focuses on the usual presentation and course of the more common, and some uncommon, epilepsies, neuromuscular disorders, neurodegenerative disorders, inflammatory disorders of the central nervous system and some other, miscellaneous conditions. The article ends with a very brief and general discussion about management issues in this age group.

  • ADEM, acute disseminated encephalomyelitis
  • CAE, childhood-onset absence epilepsy
  • CPT-2, carnitine-palmitoyl transferase type II
  • EEG, electroencephalogram
  • GTCS, generalised tonic–clonic seizures
  • HMSN, hereditary motor and sensory neuropathy
  • JAE, juvenile absence epilepsy
  • JME, juvenile myoclonic epilepsy
  • MRI, magnetic resonance imaging
  • PKAN, panthotenate kinase-associated neurodegeneration
  • PME, progressive myoclonic epilepsy

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    BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health