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Radiological findings in cyclical administration of intravenous pamidronate in children with osteoporosis
  1. C Onwuneme,
  2. K Abdalla,
  3. N Cassidy,
  4. O Hensey,
  5. S Ryan
  1. Children’s University Hospital, Temple Street, Dublin, Ireland
  1. C Onwuneme, Children’s University Hospital, Temple Street, Dublin 1, Ireland; drchike2001{at}

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A 5-year-old boy with moderately severe osteogenesis imperfecta and spontaneous fractures was treated with serial courses of intravenous pamidronate. Pamidronate is a second-generation bisphosphonate drug that binds strongly to bone mineral and interferes with bone remodelling by slowing osteoclastic bone resorption. It is used in a cyclic dosage …

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