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In neonates requiring intravascular volume resuscitation is the use of gelofusine safe and efficacious?
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  • Published on:
    Gelofusine and NEC – an inappropriate conclusion

    Sir,

    The Archimedes offering by Khashu and Balusubramaniam [1] contains an overstatement of the evidence from our Cochrane Review [2] (Early volume expansion for prevention of morbidity and mortality in very preterm infants) in suggesting in their 'Clinical Bottom Line' that "Weak evidence suggests an increased risk of necrotising enterocolitis with use of Gelofusine in neonates”. We had cautioned against over i...

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    Conflict of Interest:
    None declared.
  • Published on:
    Re: Gelofusine and NEC - a misleading conclusion

    Dear Dr.Richmond,

    Thankyou for your e letter.

    In the relevant review by Osborn and Evans, (2004) subgroup analysis: Gelatin based plasma substitute versus FFP, the authors clearly state under secondary outcomes:

    The rate of NEC was significantly higher (RR 4.92, 95% CI 1.44, 16.80) in infants who received the gelatin based plasma substitute.

    We agree that analysis 5.11 demonstrate...

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    Conflict of Interest:
    None declared.
  • Published on:
    Gelofusine and NEC - a misleading conclusion

    Sir,

    The Archimedes offering by Khashu and Balusubramaniam contains a serious error as well as a somewhat eccentric spelling of gelofusine. They suggest in their 'Clinical Bottom Line' (bullet point 3) that "Weak evidence suggests and increased risk of necrotising enterocolitis with use of Gelofuscine (sic) in neonates (Grade B)". In fact there is no such evidence, weak or otherwise.

    Analysis 05.11 in...

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    Conflict of Interest:
    None declared.