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  1. Howard Bauchner, Editor in Chief

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    THE MYSTERIES OF IMMUNISATION

    A very wise colleague of mine once told me that it is very hard to predict how immunisations will react with each other, particularly with respect to immunogenicity. As new combination vaccines are produced, often by different manufacturers with slightly different antigens, and immunisation schedules change, we should not assume that immunogenicity will remain unchanged. Nicolas Kitchin and colleagues describe changes in the immune response following the administration of DTaP-IPV-Hib vaccine with one of two different meningococcal group C conjugate vaccines at 2, 3 and 4 months of age. Andrew Pollard adds an erudite discussion of vaccine immunogenicity. Unfortunately, as we add more and more vaccines to the immunisation schedule, and adolescent vaccination becomes critical, we are likely to see an increase in the number of variable immune responses.
    See pages 1 and 11

    SEPTICAEMIA IN CHILDREN WITH SICKLE CELL DISEASE IN AFRICA

    I have cared for children with sickle cell disease for over 25 years. Prior to penicillin prophylaxis, death and disability from invasive pneumococcal …

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