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Does splenectomy in cystic fibrosis related liver disease improve lung function and nutritional status? A case series
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  • Published on:
    Re: spenectomy in cystic fibrosis

    Dear Editor,

    Not only might the risk of overwhelming sepsis after splenectomy have been exaggerated (1) even in children but any impairment in immune function might have an enteral rather than an asplenic origin. A fall in gut intramucosal pH, which may induced not only by endotoxaemia and sepsis but also by haemorrhage, may be accompanied by significant reductions in the number of T lymphocytes in the villi and inc...

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    Conflict of Interest:
    None declared.
  • Published on:
    Enteric origins to hepatic and pulmonary dysfunction in cystic fibrosis?

    Dear Editor,

    I have considered the possiblity that asthma might have an enteric origin in the past (1) but did not include some of the more compelling data (2,3). Nielsen et al's data are particularly compelling demonstrating in addition the possible relevance of gut dysfunction in the evolution of hepatic diseases.

    The demonstration that the pH of breath condensate is significantly lower in patients with...

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    Conflict of Interest:
    None declared.
  • Published on:
    Splenectomy in cystic fibrosis

    Dear Editor,

    Splenectomy in cystic fibrosis (CF) remains controversial mainly because the spleen is considered indispensable in this disease for its important immunological function in the defence against the frequent infections. Furthermore centres which perform liver transplantation prefer this approach, even early after CF related liver disease (CFLD), becomes obvious, since it seems more ethiological.

    ...

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    Conflict of Interest:
    None declared.