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Survival probability in ataxia telangiectasia
  1. T O Crawford1,2,
  2. R L Skolasky1,
  3. R Fernandez3,
  4. K J Rosquist2,
  5. H M Lederman2
  1. 1Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
  2. 2Department of Pediatrics, The Johns Hopkins Hospital
  3. 3Ataxia Telangiectasia Children’s Project, Deerfield Beach, Florida, USA
  1. Correspondence to:
    Dr Thomas O Crawford
    Pediatric Neurology, Johns Hopkins Hospital, Jefferson 123, 600 N Wolfe Street, Baltimore, MD 21287, USA; tcrawfo{at}


Ataxia telangiectasia is a rare, multiorgan neurodegenerative disorder with enhanced vulnerability to cancer and infection. Median survival in two large cohorts of patients with this disease, one prospective and one retrospective, is 25 and 19 years, with a wide range. Life expectancy does not correlate well with severity of neurological impairment.

  • ATCC, Ataxia Telangiectasia Clinical Center at Johns Hopkins Hospital
  • ATCP, Ataxia Telangiectasia Children’s Project
  • survival analysis
  • cancer
  • ataxia telangiectasia

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