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No clinical evidence of hidden vCJD in UK children
  1. C M Verity1,
  2. A M Winstone1,
  3. L Stellitano1,
  4. A Nicoll2,
  5. R G Will3
  1. 1Addenbrookes Hospital, Cambridge, UK
  2. 2Communicable Disease Surveillance Centre, London, UK
  3. 3National Creutzfeldt-Jakob Surveillance Unit, Western General Hospital, Edinburgh, UK
  1. Correspondence to:
    Dr Christopher M Verity
    Child Development Centre, Box 107, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK; christopher.verity{at}


Between May 1997 and November 2004 this national prospective surveillance study identified 1007 children with “progressive intellectual and neurological deterioration” (PIND). In most cases specific diagnoses were made, but of 92 undiagnosed children with PIND 46 had died and only four underwent full necropsy. There was no clinical evidence of variant Creutzfeldt-Jakob disease (vCJD) in these undiagnosed cases, but without necropsy it is not possible to exclude vCJD completely.

  • PIND, progressive intellectual and neurological deterioration
  • vCJD, variant Creutzfeldt-Jakob disease
  • variant CJD
  • PIND
  • neurodegenerative diseases
  • necropsy

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