Article Text

Download PDFPDF
Influenza virus associated encephalopathy
  1. R Surtees1,
  2. C DeSousa2
  1. 1UCL Institute of Child Health, London, UK
  2. 2Great Ormond Street Hospital for Children, London, UK
  1. Correspondence to:
    Prof. R Surtees
    The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK; R.Surtees{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Perspective on the paper by Hosoya et al (see page 469)

The neural complications of influenza are shown in box 1. The commonest of these, particularly in young children from Japan and Taiwan, is influenza virus associated encephalopathy. Influenza virus associated encephalopathy is an acute non-inflammatory encephalopathy that presents with seizures and coma on the day, or the day after, influenza symptoms start.1 Influenza is characterised by the abrupt onset of a fever greater than 39°C, respiratory symptoms (rhinorrhoea, cough, and sore throat), myalgia (particularly of the back and limb muscles), and headache.2 In infants symptoms are often lethargy, poor feeding, apnoea, and interstitial pneumonia; older children may also have less specific symptoms of croup, otitis media, diarrhoea, and vomiting.

Box 1: Neural complications of influenza infection

  • Encephalopathy

  • Encephalitis

  • Reye syndrome

  • Febrile convulsion

  • Myelitis

  • Guillaine-Barré syndrome


Influenza virus associated encephalopathy is a disease of young children with a peak incidence between 6 and 18 months of age.1 It has mostly been reported from Japan and Taiwan, but cases have been reported from Europe and North America and in Caucasian children.3 It is a severe disorder with a fatality of around 30%, and persisting neurodisability in around one third of survivors, associated with cerebral atrophy. The majority of cases complicate influenza A infections, but influenza B is responsible for around 10%.

Rapidly progressive neurological deterioration, seizures, and coma occur around 26 hours after the onset of influenza symptoms. Neuroimaging shows cerebral oedema in the …

View Full Text


  • Competing interests: none declared

Linked Articles