You are here

Article Text

Article menu
Download PDFPDF
Archimedes
Should children with ADHD and normal intelligence be routinely screened for underlying cytogenetic abnormalities?
  1. E Stephen,
  2. A D Kindley
  1. Royal Aberdeen Children’s Hospital, Aberdeen, UK; elma.stephen@arh.grampian.scot.nhs.uk

https://doi.org/10.1136/adc.2006.100461

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    You are assessing a 7 year old boy with attention and behaviour difficulties, and poor school performance. He has an average IQ and meets the diagnostic criteria for attention deficit hyperactivity disorder (ADHD). There is no evidence of developmental delay, dysmorphism, or other physical abnormalities and no relevant family history. Parents are keen on investigation for a “cause” for his problems. You are aware that some chromosomal and cytogenetic abnormalities may be associated with ADHD. You wonder if you should check karyotype and look for cytogenetic abnormalities with genetic implications for the family.

    Structured clinical question

    Should children with ADHD and normal intelligence [subject] be routinely screened* [intervention] for underlying cytogenetic abnormalities [outcome with genetic implications]?

    Search strategy and outcome

    OVID Medline and EMBASE search: “ADHD” AND (“cytogenetics” OR “human chromosomes”). A total of 61 articles were obtained combining these searches. After searching abstracts, 10 relevant articles were retrieved. (The remainder were mainly …

    View Full Text

    Footnotes

    • ↵* Karyotype, fragile X mutation analysis, FISH for 22q11.2 deletion, and high resolution chromosome banding for other cytogenetic abnormalities.

    • Bob Phillips