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Neurology

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G106 A REVIEW OF ANTIEPILEPTIC THERAPY AND SEIZURE CONTROL IN A SPECIALISED CENTRE FOR YOUNG PEOPLE WITH EPILEPSY (NCYPE)

P. Robertson1, P. Nicolaides2, S. Aylett2, R. Scott3, K. B. Das1.1NCYPE, Lingfield, UK; 2Great Ormond Street Hospital for Children, London, UK; 3Institute of Child Health, London, UK

Objective: The NCYPE is a national residential centre for students with complex epilepsy. The aim of the study was to compare the treatment with specific reference to usage of anticonvulsant drugs at admission and at discharge, and attempt to classify their epilepsy.

Methods: A retrospective review of case notes, seizure diaries, EEG, and neuroimaging of the student graduates in July 2004 was undertaken comparing the initial and final 12 months of their placement at NCYPE. Classification of their epilepsy was attempted based on the terminology proposed by the ILAE (2001).

Results: 38 of the 47 graduates (age 16.9 to 24.1 years; 24 males, 14 females) had a diagnosis of epilepsy; 24 (63.2%) with symptomatic/probably symptomatic focal epilepsy, 5 of whom underwent epilepsy surgery. The remaining diagnostic groups included idiopathic generalised epilepsy, 6 (15.8%); SMEI, 2 (5.3%); Lennox Gastaut syndrome, 1 (2.6%); and unclassifiable in 5 (13.2%). The median length of stay was 4.9 years. Their median number of AEDs remained unchanged (2 AEDs/patient). A total of 30 (78.9%) students had a reduction in reported seizure frequency, with 16 (42.1%) having more than 75% reduction in the frequency of seizures. Twelve (31.6%) had a reduction of 25% or more in the reported use of rescue medications; with no change in 20 (52.7%). Five students (13.2%) had a >75% reduction in the frequency of status epilepticus, whereas it remained unchanged in the rest.

Conclusions: This study suggests that management of refractory epilepsy in specialised epilepsy centres may have beneficial effect on seizure frequency and morbidity. In contrast to other studies, seizure …

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