Chronic non-bacterial osteomyelitis (CNO) in children may present as single or multiple lesions and there may be a single episode or recurrent episodes. Chronic recurrent multifocal osteomyelitis (CRMO) is thought to be the childhood equivalent of the synovitis, acne, pustulosis, hyperostosis, and osteitis/osteomyelitis (SAPHO) syndrome that affects adults. Although there have been reports of bacterial growths from CRMO lesions (Staphylococcus aureus, Mycoplasma hominis, Propionibacteriumacnes, Bartonela henselae, and Coxiella burnetti have all been reported) most microbiological studies, including PCR testing, have given negative results. Antibiotic treatment does not work but anti-inflammatory …