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Acute paediatrics
Lethal cardiomyopathy in epidermolysis bullosa associated with amitriptyline
  1. S M Taibjee1,
  2. P Ramani2,
  3. R Brown2,
  4. C Moss1
  1. 1Department of Dermatology, Birmingham Children’s Hospital, UK
  2. 2Department of Histopathology, Birmingham Children’s Hospital, UK
  1. Correspondence to:
    Dr S M Taibjee
    Department of Dermatology, Birmingham Children’s Hospital, Steelhouse Lane, Birmingham B4 6NH, UK; saleemtaibjeeblueyonder.co.uk

Abstract

There are previous reports of dilated cardiomyopathy (DCM) in recessive dystrophic epidermolysis bullosa (RDEB), a debilitating blistering skin disorder. The pathogenesis of DCM in RDEB remains uncertain, although dietary deficiency of selenium and carnitine have been implicated. A 6 year old girl with RDEB who died of DCM is reported; attention is drawn to the possible role of two potentially cardiotoxic drugs, amitriptyline and cisapride.

  • DCM, dilated cardiomyopathy
  • RDEB, recessive dystrophic epidermolysis bullosa
  • amitriptyline
  • cisapride
  • dilated cardiomyopathy
  • epidermolysis bullosa
  • recessive dystrophic

https://doi.org/10.1136/adc.2004.068775

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    Footnotes

    • Competing interests: none declared

    • Consent was obtained for publication of the patient detailed in this case report