Article Text

PDF

Respiratory illness associated with influenza and respiratory syncytial virus infection
  1. D M Fleming,
  2. R S Pannell,
  3. A J Elliot,
  4. K W Cross
  1. Birmingham Research Unit of The Royal College of General Practitioners, Birmingham, UK
  1. Correspondence to:
    Dr D M Fleming
    Birmingham Research Unit of The Royal College of General Practitioners, Lordswood House, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK; dflemingrcgpbhamresunit.nhs.uk

Abstract

Aims: To estimate excess morbidity during periods of influenza and respiratory syncytial virus (RSV) activity.

Methods: Retrospective analysis of a sentinel practice network database in active and non-active virus periods. Main outcome measures: clinical diagnoses of new episodes of influenza-like illness (ILI), acute bronchitis, asthma, and otitis media.

Results: The clinical diagnosis of ILI was consistent with influenza virus activity and acute bronchitis with RSV. During periods of virus activity, estimates of excess morbidity in children aged 1–4 and 5–14 years diagnosed as having acute otitis media exceeded those diagnosed with each of the other three conditions; in children <1 year estimates for acute bronchitis were highest. Using a broad definition of virus activity and summarising the data for all children diagnosed with ILI, 60% was attributable to influenza (40% RSV) as were 37% of episodes diagnosed as acute bronchitis, 9% of those with asthma and 48% of those with otitis media. Using a narrow definition, corresponding proportions were: for ILI diagnoses 77% (23% RSV), acute bronchitis 32%, asthma zero, and otitis media 45%. Acute bronchitis was diagnosed twice as frequently in association with RSV as with influenza in all age groups: excess asthma episodes were only evident in RSV active periods.

Conclusions: Except in relation to ILI, RSV caused more illness than the influenza virus in the respiratory diagnoses examined, emphasising the need for RSV prevention and treatment. Influenza was not associated with excess asthma episodes.

  • HPA, Health Protection Agency
  • ILI, influenza-like illness
  • RSV, respiratory syncytial virus
  • WRS, Weekly Returns Service
  • influenza
  • respiratory syncytial virus
  • acute bronchitis
  • asthma
  • otitis media

Statistics from Altmetric.com

Footnotes

  • Competing interests: none

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.