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Rule of three
  1. Bob Phillips
  1. Evidence-based On Call, Centre for Evidence-based Medicine, University Dept of Psychiatry, Warneford Hospital, Headington OX3 7JX, UK; bob.phillips@doctors.org.uk

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    There are many “rules of three” in medicine, but one in particular stands out in the practice of critical appraisal and evidence based medicine. It’s the rule first described by Handley and Lippmann-Hand in 1983,1 and applies to situations where a study has found no events, or alternatively, …

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