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DRUG DOSING IN CHILDREN – A REVOLUTION IS COMING
Paediatric drug dosing requires attention to the weight of the child. Virtually every drug listed in Medicines for Children contains a reference to the appropriate dose for children expressed as mg/kg. Cranswick and Mulholland describe this current approach as procrustean. Their perspective and the original article by Schaaf and colleagues from South Africa, which describes the pharmacokinetics of isoniazid based upon age and specific genotype for acetylation, suggest the future – a time when virtually every drug that we prescribe for children will be based upon age, weight, gender, and genotype.
See pages 551 and 614
HHV-6 AND -7: HOW OFTEN DO THEY CAUSE CONVULSION?
Conclusions based upon case series can be very misleading. In a study conducted through the British Paediatric Surveillance Unit, Ward and colleagues describe the relationship between human herpesvirus (HHV)-6 and HHV-7 infection and convulsions in hospitalised children. They found that 25 of 156 children aged 2–23 months with seizures and fever had primary infection with either one of these herpes viruses. Because of the way cases were identified, this report could leave us with the impression that HHV-6 and -7 infections are often associated with serious neurological disease. This would be incorrect. In a natural …
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