You are here

Article Text

Article menu
Download PDFPDF
Acute paediatrics
Chemokine response in children with SARS
  1. P C Ng1,
  2. C W K Lam2,
  3. A M Li1,
  4. C K Wong2,
  5. T F Leung1,
  6. F W T Cheng1,
  7. K L E Hon1,
  8. I H S Chan2,
  9. E Wong3,
  10. T F Fok1
  1. 1Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong
  2. 2Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
  3. 3Centre for Clinical Trials and Epidemiological Research, Prince of Wales Hospital, The Chinese University of Hong Kong
  1. Correspondence to:
    Prof. P C Ng
    Department of Paediatrics, Level 6, Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong; pakcheungngcuhk.edu.hk

Abstract

The chemokine response of eight children with serologically confirmed severe acute respiratory syndrome (SARS) was longitudinally monitored. All had raised plasma interferon γ inducible protein (IP-10) concentrations, which suggested an active type 1 T-helper lymphocyte mediated immune response. High circulating IP-10 levels could facilitate viral clearance and might play a role in assisting the recovery of the patients.

  • IP-10, interferon γ inducible protein
  • MCP-1, monocyte chemoattractant protein 1
  • MIG, monokine induced by interferon γ
  • RANTES, regulated on activation normal T cell expressed and secreted
  • SARS, severe acute respiratory syndrome
  • SARS-CoV, SARS coronavirus
  • Th1, type 1 T helper
  • chemokines
  • SARS

https://doi.org/10.1136/adc.2004.053660

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Funding: This project is funded by the Department of Chemical Pathology, The Chinese University of Hong Kong

    • Competing interests: none declared