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Interpreting immunogenicity data in UK studies
  1. J E Berrington,
  2. A Fenton
  1. Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; jberrington@doctors.org.uk

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It has become increasingly clear that interaction between vaccines is an important consideration for immunogenicity studies. Only full information on all vaccines used in a particular population will allow correct interpretation of immunogenicity data.1 This is particularly important where comparison is made to historical controls in a rapidly changing schedule such as that used in the UK, or where immunogenicity data obtained using vaccines that differ significantly from those currently in use are subsequently used to guide practice.

It also apparent that the “best” combination of specific vaccines, the effects of interactions of conjugate proteins, the optimal timing of the primary course, and the necessity for boosters within the UK schedule are all currently unclear. Certain groups of infants …

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