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In presenting various therapeutic approaches for the management of cystic fibrosis (CF), Smyth primarily considers evidence obtained from The Cochrane Library as either systematic reviews of randomised controlled trials (RCTs) or RCTs.1 The antibiotic treatment of Pseudomonas aeruginosa (PA) when first isolated, is still an open question. When discussing this aspect, Smyth considers only the RCT by Valerius and …
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