We read with interest the recent paper from Barnett and colleagues,¹ reporting the impact of different styles of informed consent forms proposed to children; it is one of the few papers on this important topic. Indeed, the content of informed consent documents (ICD) is a crucial element in the process of providing information to participants in biomedical research. Clear comprehension of this information—that is, the ability to understand its meaning and its consequences, is of great importance. However, investigators sometimes have the feeling that volunteers do not fully understand the major concepts of the study in which they are enrolled, and this issue is specifically relevant to children. This feeling has been confirmed by several studies in adults. A study conducted in two public hospitals² showed that 40.7% and …