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G44 HEALTH RELATED QUALITY OF LIFE AND ITS DETERMINANTS IN HEAD INJURED CHILDREN 1 AND 6 MONTHS AFTER INJURY

A. L. Curran, H. E. Miller, R. J. McCarter, L. Hunt, A. Brownsdon, P. M. Sharples, and the Kids Head Injury Study Group. Frenchay Hospital, Bristol

Introduction: Traumatic brain injury (TBI) is a major cause of hospital admission in childhood yet few published data exist concerning health related quality of life (HRQL) after TBI or the factors which determine HRQL.

Aims: (1) To measure health related quality of life (HRQL) in TBI children admitted to hospital 1 and 6 months after injury; (2) to compare HRQL in TBI children to that in uninjured controls; and (3) to explore the factors related to HRQL.

Methods: Prospective cohort study. TBI was classed by Glasgow Coma Score (GCS) as severe (GCS 3–8), moderate (GCS 9–12), or mild (GCS 13–15). HRQL was assessed by Pediatric Quality of Life Scale (PedsQL). Cognitive response was assessed by the WISC–III. Psychological response was assessed by Birleson Depression Scale (BDS), Impact of Events Scale (IES), Revised Children’s Manifest Anxiety Scale (RCMAS), and Child Behaviour Checklist (CBCL). Maternal depression was assessed by Beck Depression Inventory II (BDI-II).

Results: 88 TBI subjects (51 severe/moderate; 37 mild) and 47 controls were recruited. At 1 and 6 months after TBI there was a significant difference for all domains of PedsQL between severe/moderate TBI and controls (physical p<0.001, p = 0.001; emotional p = 0.003, p = 0.003; school p<0.001, p<0.001; social p<0.001, p = 0.001) but not between mild TBI and controls. There was significant correlation between all domains of PedsQL and maternal depressive symptomatology 1 and 6 months after TBI (p<0.001; p = 0.002) and between all domains of PedsQL and CBCL (physical p = 0.001, p = 0.001; emotional p = 0.001, p<0.001; social p<0.001, p<0.001; school p<0.001, p<0.001). At 1 month there was a significant correlation between physical, social, and school domains and performance IQ (PIQ) (p = 0.005, p = 0.006, p = 0.001), between school domain and verbal IQ …

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