Article Text

Download PDFPDF

Is an intravenous fluid bolus of albumin or normal saline beneficial in the treatment of metabolic acidosis in a normovolaemic newborn?
Free
  1. Hassib Narchi
  1. Consultant Paediatrician, Sandwell & West Birmingham NHS Trust, UK; hassibnarchi@hotmail.com

    Statistics from Altmetric.com

    At the age of 4 hours, a tachypnoeic, well hydrated, well perfused, and normotensive 34 week preterm neonate develops a metabolic acidosis (arterial pH 7.25, base deficit minus 10 mmol/l). There was no history of perinatal blood loss or sepsis risk factors. No resuscitation was required at birth, and the cord blood pH was 7.3. According to departmental protocol, volume expansion with an intravenous bolus of 10–20 ml/kg of normal saline or 4.5% albumin is advised. You wonder as to the value of this volume expansion.

    Structured clinical question

    In the absence of asphyxia or hypovolaemia in a newborn infant with metabolic acidosis [patient] does an intravenous bolus of normal saline or albumin [intervention] improve the following [outcomes]: pH, base deficit, mortality, morbidity, length of hospital stay, neurodevelopmental disability? …

    View Full Text

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.