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LETTER
Thrombocytopenia is predictive of lethality in severe childhood falciparum malaria
  1. C Rogier1,
  2. P Gerardin2,
  3. P Imbert3
  1. 1Parasitology Unit, Institut de Médecine Tropicale du Service de Santé des Armées–IFR 48, Le Pharo, Marseille, France; christophe.rogier@wanadoo.fr
  2. 2Neonatal and Pediatric Intensive Care Unit, Hôpital Alfred Isautier, Saint-Pierre, Reunion Island, France
  3. 3Department of Infectious Diseases and Tropical Medicine, Hôpital d’Instruction des Armées Bégin, Saint-Mandé, France

https://doi.org/10.1136/adc.2003.045179

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    Moulin and others1 reported that thrombocytopenia was not a marker of severity in children suffering falciparum malaria. In a previously published study,2 we have shown a highly significant association between thrombocytopenia and either severity or prognosis in childhood falciparum malaria. To our knowledge, this association had not been noted3 or looked for4 before.

    Our study took place from October 1997 to March 1999, in the paediatric department of the Hopital Principal in Dakar, Senegal, where clinical presentation, WHO criteria of severe malaria, and platelet count were prospectively recorded. Of 288 falciparum cases, 215 matched the 2000 WHO definition of severe malaria. Median platelet counts were lower (98 000/mm3 versus 139 000/mm3; p < 0.02) among severe cases than in mild cases, …

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