Article Text

Download PDFPDF

Effectiveness of influenza vaccine for the prevention of asthma exacerbations
  1. C Christy1,
  2. C A Aligne2,
  3. P Auinger3,
  4. T Pulcino1,
  5. M Weitzman3
  1. 1Strong Children’s Research Center, Rochester General Hospital, Rochester, NY, USA
  2. 2Pediathink, Rochester, NY, USA
  3. 3Department of Pediatrics, University of Rochester School of Medicine & Dentistry, the American Academy of Pediatrics Center for Child Health Research, USA
  1. Correspondence to:
    Dr C Christy
    Rochester General Hospital, Department of Pediatrics, 1425 Portland Avenue, Rochester, NY 14621-3095, USA;


Background: There is a lack of clinical evidence that annual vaccination against influenza prevents asthma exacerbations in children.

Methods: Retrospective cohort study of 800 children with asthma, where one half did, and the other half did not receive the influenza vaccine. The two groups were compared with respect to clinic visits, emergency department (ED) visits, and hospitalisations for asthma. In multivariable analyses, adjustment was made for baseline asthma severity, prior utilisation of health services, receipt of vaccine in the previous year, and demographic variables.

Results: After adjusting for other variables, the vaccine group had a significantly increased risk of asthma related clinic visits and ED visits (odds ratios 3.4 and 1.9, respectively).

Conclusion: This study failed to provide evidence that the influenza vaccine prevents paediatric asthma exacerbations.

  • influenza vaccine
  • asthma
  • influenza vaccine
  • asthma
  • vaccination
  • human
  • retrospective studies
  • cohort studies

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.