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Ibuprofen and acute renal failure in a toddler
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  • Published on:
    Ibuprofen and acute renal failure

    Dear Editor

    In our modern era of evidence based practice, I was disappointed to see that the discussion of this case took no account of the weight of evidence that is widely published against its final conclusion i.e. that ibuprofen was the root cause of acute renal failure in their case.

    Whilst case reports are an interesting way of learning about new diseases or reporting new findings, it was, in my opin...

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    Conflict of Interest:
    None declared.
  • Published on:
    Estimation of risk requires a denominator

    Dear Editor

    Although it is reasonable to highlight an adverse event associated with a drug, it is also important to attempt to estimate the risk for the adverse event. The best estimate of risk associated with a treatment would come from a large randomised controlled trial.

    The Boston University Fever Study compared paracetamol (12 mg/kg) with ibuprofen (5 or 10 mg/kg) in 27,065 children under the age...

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    Conflict of Interest:
    None declared.