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The progression of maternal RSV antibodies in the offspring
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  1. M Hacimustafaoglu1,
  2. S Celebi1,
  3. E Aynaci2,
  4. M Sinirtas3,
  5. N Koksal4,
  6. A Kucukerdogan5,
  7. I Ercan6,
  8. G Goral3,
  9. I Ildirim1
  1. 1Uludag University Medical Faculty, Department of Pediatrics and Pediatric Infectious Diseases, Görükle, Bursa, Turkey
  2. 2Uludag University Medical Faculty, Department of Pediatrics, Görükle, Bursa, Turkey
  3. 3Uludag University Medical Faculty, Department of Department of Infectious Diseases and Microbiology, Görükle, Bursa, Turkey
  4. 4Uludag University Medical Faculty, Department of Pediatrics, Division of Neonatology, Görükle, Bursa, Turkey
  5. 5Zubeyde Hanim Maternity Hospital, Bursa, Turkey
  6. 6Uludag University University Medical Faculty, Department of Biostatistics, Görükle, Bursa, Turkey
  1. Correspondence to:
    Dr M Hacimustafaoglu
    Uludag University Medical Faculty, Department of Pediatrics and Pediatric Infectious Diseases, 16059, Görükle, Bursa, Turkey; mkemaluludag.edu.tr

Abstract

The concentrations of maternal anti-RSV IgG antibodies were followed in 49 healthy newborns over the first six months of life.

At birth, 41 mothers (83%) tested positive for anti-RSV IgG and all of their babies carried maternal anti-RSV IgG. Anti-RSV IgG positivity dropped to 73% at 1 month, 6% at 3 months, and 2% at 6 months.

Between 3 and 6 months, 8% did acquire RSV infection, half of them as acute bronchiolitis and half as non-specific respiratory infection. All of the patients who acquired clinical RSV disease had an antibody concentration of <20 RU/ml which may be the cut off value for protection.

  • respiratory syncytial virus
  • maternal antibodies
  • epidemiology
  • AB, acute bronchiolitis
  • RSV, respiratory syncytial virus
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Footnotes

  • This investigation was funded by the Uludag University Research Fund

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