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You are an intensive care registrar who has taken over the care of a 3 week old baby boy diagnosed as having clinical bronchiolitis (now found to be RSV+). He was initially admitted and ventilated because of increasing respiratory distress and apnoeas. His ventilatory requirements are increasing and gas exchange is getting worse. You have just finished your stint on neonates and recall hearing that surfactant has been used on infants with bronchiolitis in trials. You wonder if it may help this child.
Structured clinical question
In an infant with severe RSV+ bronchiolitis requiring ventilation [patient], does endotracheal surfactant [intervention]; (a) improve ventilation/gas exchange parameters; and (b) shorten the duration of ventilation or intensive care stay [outcome]?
Search strategy and outcome
A search string of (a) [bronchiolitis] and [surfactant] and (b) [respiratory syncytial virus] and [bronchiolitis] was used.
Cochrane database—topic …
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Bob Phillips
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