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Kasabach-Merritt syndrome and interferon alpha: still a controversial issue
  1. P Biban1
  1. 1PICU, Major City Hospital, Verona;

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We read with interest the paper by Akyuz and colleagues,1 which described a 2 year old patient with a Kasabach-Merritt syndrome (KMS) secondary to an infiltrating angiolipoma, who was successfully treated with interferon alpha 2a (IFN-alpha).

The authors did not emphasise the increasing body of concerns associated with the use of IFN-alpha in children affected by KMS. Indeed, several authors have recently warned about potential adverse effects related to the use of this drug, the most worrisome being spastic diplegia.2–4

Although IFN-alpha has been shown to be an …

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