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Moderately high doses still need to be considered for very young children
  1. D P Cochran
  1. Respiratory Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, UK; dominic.cochran{at}

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In relation to the question of adrenal suppression when using higher doses of inhaled corticosteroid, I believe there is an aspect of dose selection which has not been mentioned by previous authors.

There are limited data on the question of intra-pulmonary drug deposition in children under 3 years but the studies that have been published seem to indicate that around 1–2% of the drug released into the spacer reaches the airways,1 compared to 15–17% in an adult using the same device. Based on this figure, it seems reasonable to prescribe similar doses to very young children and adults alike.

I note that none of the cases of adrenal impairment have been reported in children under 3 years of age; most of them are significantly older. This could be partly because higher doses are not being used in this age group, but might also be confirmation that a smaller fraction of the drug reaches the airways.

I would argue that there are good reasons to use higher doses, at least initially, when treating very young children. The diagnosis of asthma is exceptionally difficult here, and if a “trial of treatment” is ineffective, one wishes to be reasonably confident that the reason for the negative response was not related to an inadequate dose. A negative response allows the clinician to withdraw ineffective steroid treatment in those infants who may well not have asthma at all. If there is an excellent response, the dose of steroid should be stepped down to the minimum required to control symptoms.

Finally, for clarity, the doses I am referring to are budesonide/beclomethasone 800 mcg/day or fluticasone 500 mcg/day.


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