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Metrorrhagia and precocious puberty revealing primary hypothyroidism in a child with Down’s syndrome
  1. W Chemaitilly1,
  2. C Thalassinos1,
  3. S Emond2,
  4. E Thibaud1
  1. 1Paediatric Endocrinology Department, Hôpital Necker Enfants Malades, Paris, France
  2. 2Paediatric Radiology Department, Hôpital Necker Enfants Malades, Paris, France
  1. Correspondence to:
    Dr W Chemaitilly, Paediatric Endocrinology Department, Hôpital Necker Enfants Malades, Paris, France;
    wassimnet{at}aol.com

Abstract

We report a child with Down’s syndrome in whom metrorrhagia and precocious puberty revealed primary autoimmune hypothyroidism. The patient had a decreased growth velocity, exaggerated weight gain, bone age delay, and bilaterally enlarged multicystic ovaries. Delays in the diagnosis and treatment of hypothyroidism can lead to this peculiar presentation.

  • precocious puberty
  • hypothyroidism
  • metrorrhagia
  • chronic autoimmune thyroiditis
  • Down’s syndrome
  • FSH, follicle stimulating hormone
  • LH, luteinising hormone
  • TRH, TSH releasing hormone
  • TSH, thyroid stimulating hormone

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