Article Text
Acute paediatrics
Metrorrhagia and precocious puberty revealing primary hypothyroidism in a child with Down’s syndrome
Abstract
We report a child with Down’s syndrome in whom metrorrhagia and precocious puberty revealed primary autoimmune hypothyroidism. The patient had a decreased growth velocity, exaggerated weight gain, bone age delay, and bilaterally enlarged multicystic ovaries. Delays in the diagnosis and treatment of hypothyroidism can lead to this peculiar presentation.
- precocious puberty
- hypothyroidism
- metrorrhagia
- chronic autoimmune thyroiditis
- Down’s syndrome
- FSH, follicle stimulating hormone
- LH, luteinising hormone
- TRH, TSH releasing hormone
- TSH, thyroid stimulating hormone