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Role of itraconazole in haematology/oncology
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  1. N A Pandya1,
  2. A A Atra1,
  3. U Riley2,
  4. C R Pinkerton1
  1. 1Department of Paediatric Oncology, The Royal Marsden Hospital NHS Trust, Institute of Cancer Research, Sutton, Surrey SM2 5PT, UK
  2. 2Department of Microbiology, The Royal Marsden Hospital NHS Trust
  1. Correspondence to:
    Professor C R Pinkerton, Institute of Cancer Research, The Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK;
    rossp{at}icr.ac.uk

Abstract

The antifungal agents most frequently used in prophylaxis and treatment are amphotericin B (and its new lipid forms) and azoles such as fluconazole, itraconazole, and more recently voriconazole. This review assesses the role of itraconazole in paediatric haematology/oncology practice. Its broader spectrum of activity and availability in oral and intravenous forms allow a flexible approach in the management of fungal infections.

  • itraconazole
  • invasive fungal infections
  • prophylaxis
  • GVHD, graft versus host disease
  • IFI, invasive fungal infections
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