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  • Successful radioiodine treatment in a 3 year old child with Graves’ disease following antithyroid medication induced neutropenia

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Acute paediatrics
Successful radioiodine treatment in a 3 year old child with Graves’ disease following antithyroid medication induced neutropenia
  1. M A S Rahman1,
  2. G Birrell4,
  3. H Stewart2,
  4. H Lucraft3,
  5. T D Cheetham4
  1. 1Department of Paediatrics, Harrogate District Hospital, Yorkshire HG2 7SX, UK
  2. 2Department of Paediatrics, University Hospital of North Durham, Durham DH1 5TW, UK
  3. 3Department of Radiotherapy, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
  4. 4Department of Paediatrics, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
  1. Correspondence to:
    Dr T D Cheetham, Department of Paediatrics, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK;
    t.d.cheetham{at}ncl.ac.uk

Abstract

A 3 year old child with Graves’ disease and mitral valve prolapse became neutropenic on carbimazole therapy. She was switched to propylthiouracil but the neutropenia recurred. She was treated with radioiodine but required two doses of 113 MBq and then 198 MBq five months later before becoming hypothyroid. The mitral valve prolapse resolved when she was euthyroid on thyroxine replacement. Antithyroid drugs, surgery, and radioiodine all have a place in the management of the thyrotoxic child.

  • thyrotoxicosis
  • antithyroid drug
  • mitral valve prolapse
  • radioiodine

https://doi.org/10.1136/adc.88.2.158

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