Article Text

Download PDFPDF
Amitraz poisoning, an emerging problem: epidemiology, clinical features, management, and preventive strategies
  1. H L Yilmaz,
  2. D R Yildizdas
  1. Cukurova University Medical School, Turkey
  1. Correspondence to:
    Dr H L Yilmaz, Yeni Baraj Mah. 1 Sok. Gülek Plaza A Blok 6/9, Adana 01550, Turkey;


Background: Amitraz is a pharmaceutical, veterinary, and agricultural product which is used worldwide under numerous generic names as an acaricide and insecticide. Because of its widespread use amitraz poisoning has come emerged as a cause of childhood poisoning during the past decade, particularly more in certain countries such as Turkey.

Aims and Methods: To report the clinical features, the management, and the preventive strategies of amitraz poisoning in nine children, and review the previously reported 137 cases in humans.

Results: Five male and four female children aged 10 months to 8 years were admitted to our department. The estimated ingested dose ranged between 89.2 and 163 mg/kg and estimated time from ingestion to presentation was 30–120 minutes. The initial signs and symptoms were impaired consciousness, drowsiness, vomiting, disorientation, miosis, mydriasis, hypotension, bradycardia, tachypnoea, hypothermia, and generalised seizures. Hyperglycaemia, glycosuria, and minimal increase in transaminase levels were observed. None required mechanical ventilation. CNS depression resolved spontaneously within 4–28 hours in all. The length of hospital stay was two to three days; all had a good outcome.

Conclusion: This review details preventive measures and management strategies of amitraz poisoning, including the importance of following patients closely in the intensive care unit, monitoring their respiratory, cardiovascular, and central nervous systems since they may occasionally experience serious cardiopulmonary side effects.

  • adrenergic agonist
  • amitraz
  • poisoning
  • ALT, alanine aminotransferase
  • AST, aspartate aminotransferase
  • BUN, blood urea nitrogen
  • CNS, central nervous system
  • ECG, electrocardiogram
  • GCS, Glasgow coma score
  • LD, lethal dose
  • MAO, monoamine oxidase

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


Linked Articles

  • Atoms
    Harvey Marcovitch