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Is indomethacin or ibuprofen better for medical closure of the patent ductus arteriosus?
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Other responses

  • Published on:
    Mannitol influence on the less renal side effects of ibuprofen vs. indomethacin for PDA closure
    • Jorge Pisapia, Pharmacist
    • Other Contributors:
      • Leonardo Giunta , M. Rosario Alonso

    Dear Editor,

    We have found very interesting Dr Erik Swartz's report(1) concerning the use of ibuprofen and indomethacin for patent ductus arteriosus (PDA) closure and we would like to include more information to be considered in order to answer Dr Swartz´s question. Several studies(2) showed the equivalence of both drugs for PDA closure in premature neonates. In addition ibuprofen was associated with less o...

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    Conflict of Interest:
    None declared.
  • Published on:
    Benefits of ibuprofen over indomethacin for the medical closure of patent ductus arteriosus.

    Dear Editor

    I read with great interest the article by Dr Erik N Swartz concerning the use of ibuprofen or indomethacin for the medical closure of patent ductus arteriosus.[1]

    I would like to highlight advantages of ibuprofen and disadvantages of indomethacin. In addition to being a nephrotoxic, indomethacin also affects cerebral & intestinal haemodynamics. Cerebral oxygen delivery is significantly a...

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    Conflict of Interest:
    None declared.