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Population pharmacokinetics of high dose ibuprofen in cystic fibrosis
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  • Published on:
    Beware of liver disease for High dose ibuprofen in cystic fibrosis

    Dear Editor

    We read also with interest the response to " High dose ibuprofen in cystic fibrosis"[1] as "Beware of liver disease" from Mordy R Muorah, and his question about if similar exclusion criteria than Konstan MW applied in his research,[2] we also did. Exclusion criteria were needed for oral steroids, or other NSAIDs, known as hypersensitivity to NSAIDs, liver disease, peptic ulcera, or cardiac, renal, hem...

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    Conflict of Interest:
    None declared.
  • Published on:
    High dose ibuprofen in cystic fibrosis: Beware of liver disease
    • Mordi R Muorah, Paediatric Hepatology SHO
    • Other Contributors:
      • Rupert Hinds and Nedim Hadzic

    Dear Editor

    We read with interest the study on the use of high dose ibuprofen in cystic fibrosis (CF) by Arranz et al.[1] Whilst we appreciate the possible beneficial effects of high dose ibuprofen on lung function, we are concerned that its non-critical use could be associated with some risks, despite monitoring of drug levels.

    The authors quote an earlier report showing that ibuprofen can be u...

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    Conflict of Interest:
    None declared.