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Melanocortin 4 receptors and obesity

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Since all obesity results from an excess of energy intake over energy expenditure it follows that too much food and too little exercise must underlie the current obesity pandemic. It is tempting to blame fast food, cars, and television, and no doubt they share a lot of the blame, but could some people affected by modern lifestyle changes be genetically predisposed to succumb? Or have the genetic syndromes always existed and are they irrelevant to the recent increase?

Leptin …

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