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Since early 1990, the incidence of sudden infant death syndrome (SIDS) has dropped sharply because of public health campaigns decrying the dangers of the prone sleep position. The other known risk factors, such as preterm birth and young maternal age, are less susceptible to prevention campaigns.1
Disordered autonomic function, including cardiorespiratory control, has been suggested to be involved in SIDS.2,3 Vagal overactivity (VO), characterised by breath holding spells and repeated syncopes in specific circumstances, has been described as a manifestation of autonomic dysfunction.4 To investigate a possible relation between VO and SIDS, we investigated 65 children presenting documented VO; for example, clinical characteristics and a positive test for eyeball compression and/or electrocardiographic monitoring. Parents of these children were interviewed about their family history, especially with respect to the occurrence of SIDS among their other children.
Among their siblings, five of 126 had died of SIDS. All five children were full term infants. The average maternal age, birth weight, and age at death were respectively 27.4 (3.5) years, 3.3 (0.3) kg, and 3.5 (1.1) months. The rates of SIDS in siblings of children with VO were compared to those in the general population using the standardised incidence ratio (SIR), which is the ratio of the observed number to the expected number of cases of SIDS calculated by French incidence rates. The expected number of SIDS was 0.17 and hence the SIR was 29.4 (95% CI 9.5 to 68.6; p < 0.000011). Our result showed an overall significant excess of SIDS among siblings of children with VO. We verified that recruited children had not come to the centre because of a family history of SIDS. Since children with a positive family history of SIDS could be followed up more regularly than others, we estimated the SIR separately among siblings of children recruited during their follow up and those of children recruited during their first visit, and verified that there was no significant difference in SIR between these cases.
Despite the marked decline in SIDS, it is still the leading cause of postneonatal mortality. Better knowledge of other risk factors may allow identification of populations at high risk and a possible decline in infant mortality from SIDS through the implementation of appropriate prevention measures. Our findings suggest that VO may be involved in SIDS and that children with VO or a family history of VO may be a population at potential high risk of SIDS.
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