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Are topical corticosteroids superior to systemic histamine antagonists in treatment of allergic seasonal rhinitis?
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Roehr CC, Forster J
Are topical corticosteroids superior to systemic histamine antagonists in treatment of allergic seasonal rhinitis?
Archives of Disease in Childhood 2002;87:412-413.

Publication history

  • First published November 1, 2002.
Online issue publication 
November 01, 2002

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    Table 1 Topical corticosteroids v systemic histamine antagonists in treatment of allergic seasonal rhinitis
    CitationStudy group and type (level of evidence)OutcomeKey resultsComment
    Weiner et al (1998)Meta-analysis of 16 RCT (total of 2267 subjects; mean age 32 years, range 12 to 75 years)Comparison INC v OH1A on nasal symptoms (itch, nasal blockage, nasal discharge, and sneezing) INC give greater relief of total nasal symptoms than OH1A Analysis based on Cochrane methodology (albeit language bias)
       Combined standardised mean difference -0.42 (95% CI -0.53 to -0.32). 
     Level of evidence 1a (SR with (predominantly) homogeneity of RCT)Comparison INC v OH1A on eye symptoms No significant difference between INC and OH1A in relieving eye symptoms Meta-analysis of 11 RCT, OH1A could be beneficial ancillary to INC for treatment of eye symptoms.
      Comparison INC v OH1A on cost effectiveness INC are more cost effective than OH1A Individual studies suggest cost effectiveness
      Total outcomeINC are recommended as 1st line treatment of allergic rhinitisSafety issues were considered
         
    van Cauwenberge et al (2000) Consensus statementAdvice on treatment of seasonal allergic rhinitisINC are recommended as 1st line treatment of moderate to severe symptoms of SARNo comment on identification of primary data or appraisal of the underlying evidence. Recommendation partially based on Weiner et al
     Level 5: expert opinion without explicit critical appraisal   
    INC, intranasal corticosteroids; OH1A, oral H1 receptor antagonists.

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Copyright 2002 Archives of Disease in Childhood