Article Text
PDFAcute paediatrics
Coeliac disease and liver dysfunction
Abstract
The spectrum and pathogenesis of liver dysfunction in coeliac disease (CD) is reviewed. CD and liver disease share common risk factors, and consequences of CD may cause liver dysfunction. Liver dysfunction should be sought in CD, and its aetiology explored when abnormalities persist after gluten exclusion. CD should be excluded in patients with unexplained liver dysfunction before being labelled “cryptogenic”.
- coeliac disease
- liver dysfunction
- screening
- AILD, autoimmune liver disease
- AIH, autoimmune hepatitis
- AISC, autoimmune sclerosing cholangitis
- ALT, alanine aminotransferase
- AST, aspartate aminotransferase
- CD, coeliac disease
- GFT, gluten free diet
- γGT, gamma glutamyl transferase
- HCV, hepatitis C virus
- HSV, herpes simplex virus
- IDDM, insulin dependent diabetes mellitus
- PBC, primary biliary cirrhosis
- PSC, primary sclerosing cholangitis
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- AILD, autoimmune liver disease
- AIH, autoimmune hepatitis
- AISC, autoimmune sclerosing cholangitis
- ALT, alanine aminotransferase
- AST, aspartate aminotransferase
- CD, coeliac disease
- GFT, gluten free diet
- γGT, gamma glutamyl transferase
- HCV, hepatitis C virus
- HSV, herpes simplex virus
- IDDM, insulin dependent diabetes mellitus
- PBC, primary biliary cirrhosis
- PSC, primary sclerosing cholangitis
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